The COVID-19 pandemic spread on hospital admissions in the Bolzano Province (Italy): a descriptive study (February 2020-March 2022)

Introduction: Italy was one of the first countries to be affected because of a severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) due to COVID-19 infection. However, the cases spread has not been consistent, featuring different tendencies over the months: in some periods cases escalated speedily and in others their expansion was indeed under restraint. Materials and methods: Based on Kaplan-Meier survival curves, the descriptive study includes the COVID-19 hospitalization in the Bolzano Province from February 2020 to March 2022 to analyze the frequency of such hospitalizations and the association between risk factors as age, sex, pandemic's wave, and the 30-day in-hospital mortality. Results: According to the results, starting from the first hospitalization, the 91.6% of in-hospital deaths occurred within 30 days, with an estimated 30-day's survival probability of 0.675 (95% CI: 0.649-0.699) for patients over 85 years of age;the estimate for male patients is 0.833 (95% CI: 0.820-0.846) and that for patients admitted during the initial wave is to 0.784 (95% CI: 0.751-0.813). Discussion and conclusions: The results of the study are in line with other studies in the literature at national and international level supporting the hypothesis that the rising age, the male sex and the first wave have played an important role in the COVID-19 mortality rate.

Safety, pitfalls, and misunderstandings about the use of ozone therapy as a regenerative medicine tool. A narrative review.

Despite various opinions and healthy controversy on Ozone Therapy (OT), the practices of this therapy have increased worldwide. Main areas of study with consistent scientific outcomes are the topical treatment of both disk herniation and periodontal disease. On the other hand, there is a net dissociation of the scientific resonance concerning systemic oxygen/ozone treatments. It is our intention to discuss in logical terms the numerous papers that commendably reported adverse reactions attributable to OT, focusing our attention mainly to the techniques of administration and not to the simple contact of ozone with biological material. The case reports on OT treatments safety concerns discussed on international journals, make it possible to state that most safety issues are secondary to infections or traumatic reactions due to malpractice. Commonly, the molecule of ozone itself is not responsible of severe reactions at the therapeutic modalities. The millions of patients treated so far from the thousands of physicians correctly practicing OT world widely in the last 40 years demonstrate the safety of this simple and cost-effective regenerative medicine tool. The promising therapeutic implications also for the current COVID-19 emergency are a further stimulus to the standardization of this therapeutic resource with multiple application specificities.

Oxygen-ozone therapy as adjuvant in the current emergency in SARS-COV-2 infection: a clinical study.

The aim of the multicentre study promoted by Nuova FIO is to evaluate the beneficial effects of the systemic Oxygen-Ozone (O2O3) therapy in patients suffering from SARS COV-2 disease in the early phases of the disease, before worsening, up to the need of tracheal intubation. The study is based on the rationale on that the systemic oxygen-ozone treatment could be effective, positively influencing the disease evolution and/or being able to mitigate the onset of the cytokine storm syndrome at least partially.